| Expression pattern: |
DN |
| Associated gene: |
S100A11 |
| Associated microRNA: |
miR-143-3p |
| Biological function: |
enhances proliferation/viability, restrains apoptosis, and facilitates EMT-associated migration and invasion of trophoblastic cells (relieves trophoblastic cell dysfunction in RPL). |
| Molecular mechanism: |
circFOXP1 acts as a ceRNA that competitively binds miR-143-3p to upregulate S100A11 in trophoblastic cells. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Western Blot; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
potential biomarkers and diagnostic targets for RPL |
| Description: |
circFOXP1 is down-regulated in RPL placental tissues. It alleviates trophoblastic cell dysfunction by acting as a miR-143-3p sponge to upregulate S100A11, thereby promoting proliferation/viability, EMT, migration and invasion, and inhibiting apoptosis. |
| Confidence score: |
0.6536 |