| Expression pattern: |
DN |
| Associated gene: |
KLLN |
| Associated microRNA: |
miR-92a-2-5p, miR-193a-5p, miR-485-5p, miR-513a-5p, miR-612 |
| Biological function: |
Inhibits RCC cell proliferation and promotes apoptosis; suppresses tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-92a-2-5p to upregulate KLLN expression (ceRNA mechanism). |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (inhibits); apoptosis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Transfection; CCK8; TUNEL; RNA Pull-Down; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
Low circAMOTL1L expression correlates with tumor stage, metastasis, and poor prognosis; low expression associated with lower overall survival rate. |
| Description: |
circAMOTL1L is down-regulated in RCC and functions as a tumor suppressor by inhibiting proliferation and promoting apoptosis. It acts as a ceRNA sponge for miR-92a-2-5p, relieving repression of KLLN and suppressing RCC growth in vitro and in a 786-O xenograft model. Low circAMOTL1L expression is associated with advanced stage/metastasis and worse survival. |
| Confidence score: |
0.7353 |