circRNA basic information
circBase ID: hsa_circ_0001351
Name: hsa_circ_GMPS
Synonym: circGMPS
Host Gene: GMPS
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

gastric normal and cancer tissues; serum; serum-derived exosomes; tumor tissues
Cell lines:

GES-1; MKN45; SGC7901; AGS; HGC-27
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: PUM1
Associated microRNA: miR-144-3p
Biological function: Promotes gastric cancer cell proliferation, migration and invasion; facilitates malignant progression of GC cells.
Molecular mechanism: Exosome-transported circGMPS acts as a ceRNA by sponging miR-144-3p to up-regulate PUM1 expression.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; Western Blot; Survival Analysis; Bioinformatics Analysis
Clinical significance:

High circGMPS expression is related to poor prognosis and circGMPS may serve as a clinical biomarker or promising biological target for GC diagnosis and treatment.
Description:

circGMPS is up-regulated in gastric cancer serum-derived exosomes, tumor tissues, GC cells and GC cell-derived exosomes, and high expression is associated with poor prognosis. Exosome-transported circGMPS promotes GC cell proliferation, migration and invasion by sponging miR-144-3p and increasing PUM1 expression, suggesting a potential biomarker and therapeutic target role.
Confidence score:

0.7078
Other information
Title:

Exosome-mediated circGMPS facilitates the development of gastric cancer cells through miR-144-3p/PUM1.

Journal: Cytotechnology
Published: 2024
PubMed ID: 38304630
Study type:

combined biological and clinical study
Data availability: All data that support the findings of this study are available from the corresponding author upon reasonable request.
Code availability: -