| Expression pattern: |
UP |
| Associated gene: |
CDKN2AIP |
| Associated microRNA: |
miR-127-5p |
| Biological function: |
Promotes tumor growth and angiogenesis in osteosarcoma. |
| Molecular mechanism: |
Acts as a sponge/competitive binder of miR-127-5p to upregulate CDKN2AIP, promoting angiogenesis. |
| Biological pathway or process: |
angiogenesis (promotes); proliferation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Transfection; Tube Formation Assay; Luciferase Reporter Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model |
| Clinical significance: |
Higher circFOXP1 expression was closely related to poorer prognosis and could predict overall survival in osteosarcoma patients. |
| Description: |
circFOXP1 is up-regulated in osteosarcoma and promotes tumor growth and angiogenesis. Mechanistically, it competitively binds miR-127-5p to relieve repression of CDKN2AIP, forming a circFOXP1/miR-127-5p/CDKN2AIP axis. High circFOXP1 expression is associated with poorer overall survival. |
| Confidence score: |
0.7169 |