| Expression pattern: |
UP |
| Associated gene: |
ROCK2 |
| Associated microRNA: |
miR-181a-5p |
| Biological function: |
Promotes proliferation and migration and inhibits apoptosis of colorectal cancer cells; promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-181a-5p, thereby relieving miR-181a-5p-mediated repression of ROCK2 and increasing ROCK2 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model; TUNEL; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circNSUN2 is up-regulated in colorectal cancer tissues and cell lines and promotes malignant phenotypes (proliferation and migration) while inhibiting apoptosis. Mechanistically, it sponges miR-181a-5p to increase ROCK2 expression, driving CRC progression and tumor growth in vivo. |
| Confidence score: |
0.6542 |