circRNA basic information
circBase ID: hsa_circ_0006470
Name: hsa_circ_MFN2
Synonym: -
Host Gene: MFN2
Genomic location(hg19): chr1:12061457-12062160:+
Genomic location(hg38): chr1:12001400-12002103:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; adjacent non-tumor tissues
Cell lines:

GES-1; AGS; BGC-823; MGC-803
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Biomarker role: decreased expression is associated with TNM stage and invasion degree; potential diagnostic biomarker for GC.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Down-regulation of hsa_circ_0006470 distinguishes GC tissues from adjacent normal tissues with AUC 0.783 (sensitivity 0.725, specificity 0.750) and is correlated with TNM stage and invasion degree.
Description:

hsa_circ_0006470 is significantly down-regulated in gastric cancer tissues and GC cell lines. Its decreased expression is associated with TNM stage and invasion degree and shows diagnostic value for GC (ROC AUC ~0.783).
Confidence score:

0.559
Other information
Title:

Down-regulation of hsa_circ_0006470 predicts tumor invasion: A new biomarker of gastric cancer.

Journal: Journal of clinical laboratory analysis
Published: 2021
PubMed ID: 34165822
Study type:

combined biological and clinical study
Data availability: All data used to support the findings of this study are included in the article.
Code availability: -