| Expression pattern: |
UP |
| Associated gene: |
IGF1R, Ago2 |
| Associated microRNA: |
miR-98-5p |
| Biological function: |
Promotes PDGF-BB-induced airway smooth muscle cell proliferation and migration, enhances inflammatory factor secretion, and inhibits apoptosis in an asthma cell remodeling model. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-98-5p, thereby regulating IGF1R expression/signaling in PDGF-BB-stimulated ASMCs. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); apoptosis (inhibits); inflammation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; ELISA; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Bioinformatics Analysis |
| Clinical significance: |
circERBB2 is upregulated in bronchial biopsy samples from asthma patients and is proposed as a therapeutic target for asthma. |
| Description: |
circERBB2 is upregulated in bronchial biopsy samples from asthma patients and in PDGF-BB-stimulated human ASMCs. Functionally, circERBB2 promotes ASMC proliferation/migration and inflammatory responses while suppressing apoptosis by sponging miR-98-5p and thereby increasing IGF1R expression/signaling. |
| Confidence score: |
0.7289 |