| Expression pattern: |
UP |
| Associated gene: |
IRS2 |
| Associated microRNA: |
miR-493-5p |
| Biological function: |
promotes GC cell viability, migration, invasion, EMT and tumor growth |
| Molecular mechanism: |
ceRNA sponge of miR-493-5p leading to increased IRS2 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circPRKDC expression was higher in the III/IV stage than that in I/II stage; serum circPRKDC ROC AUC=0.8572 for diagnosing GC |
| Description: |
circPRKDC is up-regulated in gastric cancer tissues/serum and promotes GC cell proliferation/viability, migration, invasion and EMT, as well as xenograft tumor growth. Mechanistically, it functions as a ceRNA that sponges miR-493-5p to increase IRS2 expression, forming the circPRKDC/miR-493-5p/IRS2 axis with diagnostic potential. |
| Confidence score: |
0.7624 |