| Expression pattern: |
UP |
| Associated gene: |
MKP1 |
| Associated microRNA: |
miR-98 |
| Biological function: |
promotes proliferation; inhibits apoptosis; promotes glycolysis; promotes glucose uptake; promotes lactate production; promotes malignant behaviors |
| Molecular mechanism: |
ceRNA mechanism: circ_0006349 sponges miR-98 to derepress/elevate MKP1 expression |
| Biological pathway or process: |
glycolysis (promotes); proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; EdU Staining; Annexin V/PI Flow Cytometry; Colony Formation Assay; TUNEL; Western Blot; Bioinformatics Analysis; Survival Analysis |
| Clinical significance: |
High circ_0006349 expression was correlated with positive lymph node metastasis, increased tumor grades, and poor tumor differentiation, and indicates dismal prognosis in patients with NSCLC. |
| Description: |
circ_0006349 is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. It mainly localizes to the cytoplasm and acts as a ceRNA to sponge miR-98, thereby increasing MKP1 expression and promoting proliferation and glycolysis while reducing apoptosis in NSCLC cells. |
| Confidence score: |
0.7896 |