| Expression pattern: |
UP |
| Associated gene: |
HK2 |
| Associated microRNA: |
miR-106a-5p |
| Biological function: |
Circ-PVT1 promotes OSCC cell growth, migration, invasion, glycolysis and tumorigenesis, and suppresses apoptosis. |
| Molecular mechanism: |
Circ-PVT1 functions as a miR-106a-5p sponge to positively regulate HK2 expression, thereby regulating OSCC cell growth, metastasis, glycolytic metabolism and tumorigenesis. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); glycolysis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
Circ-PVT1 down-regulation was proposed as an alternative molecular therapeutic strategy for OSCC. |
| Description: |
Circ-PVT1 is up-regulated in OSCC tissues and cell lines. It acts as an oncogenic circRNA by sponging miR-106a-5p to increase HK2 expression, promoting cell growth, migration, invasion, glycolytic metabolism and xenograft tumor growth while inhibiting apoptosis. |
| Confidence score: |
0.7177 |