circRNA basic information
circBase ID: -
Name: hsa_circ_SHOC2
Synonym: chr10_110964124_110965061_+
Host Gene: SHOC2
Genomic location(hg19): chr10:112723882-112724819:+
Genomic location(hg38): chr10:110964124-110965061:+
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma exosomes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: SHOC2, chr10:110964124:G>-
Associated microRNA: -
Biological function: potential plasma exosomal biomarker for CRC
Molecular mechanism: related to splice acceptor variant near SHOC2 (chr10:110964124:G>-)
Biological pathway or process:

not specified
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

elevated in plasma exosomes from CRC
Description:

chr10_110964124_110965061_+ (SHOC2-derived) is elevated in plasma exosomes from CRC and is reported as mutation-related (chr10:110964124:G>-, splice acceptor variant), supporting its potential relevance as an exosomal cancer-associated circRNA.
Confidence score:

0.1768
Other information
Title:

Machine Learning-Based Comparative Analysis of Pan-Cancer and Pan-Normal Tissues Identifies Pan-Cancer Tissue-Enriched circRNAs Related to Cancer Mutations as Potential Exosomal Biomarkers.

Journal: Frontiers in oncology
Published: 2021
PubMed ID: 34604037
Study type:

bioinformatics study
Data availability: exoRbase (Sequence Read Archive raw RNA sequencing data); Supplementary Material
Code availability: GitHub repository ()