| Expression pattern: |
UP |
| Associated gene: |
372 mRNAs |
| Associated microRNA: |
miR-370, miR-626, miR-637, miR-648, miR-326, miR-574-5p |
| Biological function: |
Prognostic biomarker for postoperative recurrence; potentially negatively associated with malignant behavior of GC. |
| Molecular mechanism: |
Predicted ceRNA network (CircInteractome/multimiR) for circRNA-miRNA-mRNA interactions; not experimentally verified. |
| Biological pathway or process: |
ceRNA regulation (other); Hippo/YAP (other); cell cycle (other); migration (other) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RT-qPCR; Clinical Sample Validation; Survival Analysis; ROC Analysis; Bioinformatics Analysis; divergent primers PCR; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RNase R Treatment |
| Clinical significance: |
High expression is associated with longer RFS and OS; part of circPanel prognostic model. |
| Description: |
hsa_circ_0002647 (from EHMT1) is upregulated in GC patients with good prognosis and its high expression is associated with longer RFS/OS. The study validates it by qRT-PCR and circularity/stability assays and uses it with hsa_circ_0005092 to build a prognostic circPanel; its ceRNA network is computationally predicted but not experimentally confirmed. |
| Confidence score: |
0.7047 |