| Expression pattern: |
UP |
| Associated gene: |
SOX5 |
| Associated microRNA: |
miR-219a-5p |
| Biological function: |
Promotes NSCLC progression by enhancing cell viability/proliferation, migration and invasion, and inhibiting apoptosis. |
| Molecular mechanism: |
circCDR1as acts as a miRNA sponge for miR-219a-5p to upregulate SOX5 (ceRNA mechanism). |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot |
| Clinical significance: |
- |
| Description: |
circCDR1as is up-regulated in NSCLC tissues and cell lines. Its knockdown suppresses malignant phenotypes (reduced viability/colony formation, migration, invasion; increased apoptosis) by acting as a ceRNA that sponges miR-219a-5p and thereby increases SOX5 expression. |
| Confidence score: |
0.6966 |