circRNA basic information
circBase ID: hsa_circ_0000745
Name: hsa_circ_SPECC1
Synonym: -
Host Gene: SPECC1
Genomic location(hg19): chr17:20107645-20109225:+
Genomic location(hg38): chr17:20204332-20205912:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

CSCC tissue; para-cancerous cervical tissues; normal cervical tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: E2F1, TFCP2, RBM41
Associated microRNA: hsa-miR-136, hsa-miR-1229, hsa-miR-1273, hsa-miR-618
Biological function: promotes CSCC cell differentiation, proliferation, and metastasis
Molecular mechanism: Predicted ceRNA mechanism (miRNA sponge) involving hsa-miR-136 (and other miRNAs) and downstream target genes identified by Oncomine analysis
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); metastasis (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

potential diagnostic and therapeutic biomarkers
Description:

hsa_circ_0000745 is up-regulated in CSCC tissues and is proposed to act through a ceRNA network by targeting miRNAs (e.g., hsa-miR-136) and affecting downstream genes such as E2F1/TFCP2/RBM41. Its overexpression is associated with promoting CSCC cell differentiation, proliferation, and metastasis.
Confidence score:

0.4032
Other information
Title:

The profile analysis of circular RNAs in cervical cancer.

Journal: Medicine
Published: 2021
PubMed ID: 34596168
Study type:

combined biological and clinical study
Data availability: GSE102686
Code availability: -