| Expression pattern: |
DS |
| Associated gene: |
circCOL6A3_030_198aa |
| Associated microRNA: |
- |
| Biological function: |
Promotes gastric cancer cell migration and metastasis (liver metastasis; lymph node metastasis association), mainly via its encoded peptide. |
| Molecular mechanism: |
circCOL6A3_030 is translated into a 198-aa peptide (circCOL6A3_030_198aa), and the peptide (rather than the RNA itself) promotes gastric cancer migration/metastasis. |
| Biological pathway or process: |
migration (promotes); metastasis (promotes); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; FISH / smFISH; Transfection; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Western Blot; Bioinformatics Analysis; ROC Analysis; Clinical Sample Validation |
| Clinical significance: |
circCOL6A3_030 provided diagnostic value for detecting lymph node metastasis of gastric cancer (ROC AUC=0.675). |
| Description: |
In gastric cancer, circCOL6A3_030 shows abnormal expression, being higher in lymph node metastasis cases. Functional assays indicate it promotes migration and in vivo liver metastasis mainly through translation into a 198-aa peptide (circCOL6A3_030_198aa), and it has potential value as a marker for lymph node metastasis. |
| Confidence score: |
0.8066 |