| Expression pattern: |
UP |
| Associated gene: |
RASA1, PLZF |
| Associated microRNA: |
hsa-miR-676-5p, hsa-miR-544b, hsa-miR-7852-3p, hsa-miR-6878-3p, hsa-miR-4789-3p, hsa-miR-6747-3p, hsa-miR-4725-5p, hsa-miR-4743-3p, hsa-miR-4649-3p, hsa-miR-4312, hsa-miR-6733-3p |
| Biological function: |
may sponge miRNA and play a role in the occurrence and development of gastric cancer; biomarker for diagnosis and post-operative/recurrence monitoring; associated with prognosis |
| Molecular mechanism: |
predicted circRNA-miRNA-mRNA regulatory axis (ceRNA); cytoplasmic post-transcriptional regulation |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; Agarose gel electrophoresis (AGE); Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Luciferase Reporter Assay; Clinical Sample Validation; ROC Analysis; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
serum hsa_circ_0007507 distinguishes GC patients from healthy donors (AUC=0.832) and decreases after surgery; higher in post-operative recurrence; high expression associated with worse survival |
| Description: |
hsa_circ_0007507 is up-regulated in gastric cancer tissues and in patient serum, and shows diagnostic value by ROC analysis. It is mainly localized in the cytoplasm and may function via a predicted/partly tested circRNA-miRNA interaction network (ceRNA-like regulation). High serum expression is associated with recurrence and worse survival, and levels decrease after surgery, supporting use in dynamic monitoring. |
| Confidence score: |
0.7894 |