circRNA basic information
circBase ID: hsa_circ_0005699
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr16:19627435-19663412:+
Genomic location(hg38): chr16:19616113-19652090:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

LUAD tissues; paracancerous tissues; tumor tissue; normal tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: HJURP, OIP5, RRM2
Associated microRNA: miR-101-3p, miR-218-5p, miR-6720-3p
Biological function: unknown
Molecular mechanism: Predicted ceRNA sponge mechanism: hsa_circ_0005699 sponges miRNAs (hsa-miR-101-3p; hsa-miR-218-5p; hsa-miR-6720-3p) to indirectly regulate HJURP, OIP5 and RRM2 in LUAD.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

Included as an upstream regulator in a circRNA-related ceRNA network used to build a prognostic risk score model associated with LUAD survival outcomes and immune landscape; no direct circRNA-level survival assessment was possible.
Description:

hsa_circ_0005699 is upregulated in LUAD in GEO-derived circRNA expression profiles and is part of a prognostic ceRNA subnetwork. It is computationally predicted to sponge miR-101-3p/miR-218-5p/miR-6720-3p and thereby influence HJURP, OIP5, and RRM2, which underlie a risk score tied to survival differences, immune infiltration patterns, and predicted drug sensitivity.
Confidence score:

0.1768
Other information
Title:

Construction of a circRNA-Related Prognostic Risk Score Model for Predicting the Immune Landscape of Lung Adenocarcinoma.

Journal: Frontiers in genetics
Published: 2021
PubMed ID: 34434213
Study type:

bioinformatics study
Data availability: GSE101684; GSE112214; TCGA; CPTAC; https://www.frontiersin.org/articles/10.3389/fgene.2021.668311/full#supplementary-material
Code availability: -