| Expression pattern: |
DN |
| Associated gene: |
MAPK1-109aa, MEK1, MAPK1 |
| Associated microRNA: |
- |
| Biological function: |
Inhibits proliferation, migration, invasion, tumorigenesis and metastasis of gastric cancer cells. |
| Molecular mechanism: |
circMAPK1 encodes a 109-aa peptide (MAPK1-109aa) that competitively binds MEK1, reducing MAPK1 phosphorylation and suppressing MAPK pathway activation and downstream factors. |
| Biological pathway or process: |
MAPK (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; EdU Staining; Cell Cycle Assay; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining; Western Blot; IF (Immunofluorescence); RIP (RNA Immunoprecipitation); Co-IP; Luciferase Reporter Assay; Bioinformatics Analysis; Survival Analysis |
| Clinical significance: |
Higher circMAPK1 levels in GC tissues predict longer overall survival; circMAPK1 may serve as a diagnostic and prognostic marker. |
| Description: |
circMAPK1 (hsa_circ_0004872) is down-regulated in gastric cancer and acts as a tumor suppressor. It inhibits GC malignant behaviors mainly by encoding MAPK1-109aa, which competitively binds MEK1 and reduces MAPK1 phosphorylation, thereby suppressing MAPK signaling. Higher circMAPK1 expression is associated with better overall survival in GC patients. |
| Confidence score: |
0.8913 |