| Expression pattern: |
UP |
| Associated gene: |
RHBDD1 |
| Associated microRNA: |
miR-548b-3p, miR-330-3p |
| Biological function: |
promotes imatinib resistance; promotes proliferation; promotes survival (anti-apoptosis) |
| Molecular mechanism: |
May act as a miRNA sponge for miR-548b-3p (predicted); associated downstream mRNAs/pathways via miR-548b-3p target genes (predicted). |
| Biological pathway or process: |
chemoresistance (promotes); proliferation (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; Bioinformatics Analysis; ROC Analysis; Transfection; CCK8; Annexin V/PI Flow Cytometry; EdU Staining; Western Blot |
| Clinical significance: |
High level of circ_0058493 was correlated with poor clinical efficacy of imatinib; ROC AUC 0.7248 for predicting efficacy. |
| Description: |
hsa_circ_0058493 is up-regulated in PBMCs of imatinib nonresponding CML patients and is enriched in exosomes from imatinib-resistant CML cells. Functional knockdown in K562/G01 increases imatinib sensitivity, increases apoptosis, and reduces proliferation. Mechanistically, it is predicted to sponge miR-548b-3p (and miR-330-3p) based on bioinformatic analysis and expression trends. |
| Confidence score: |
0.7507 |