circRNA basic information
circBase ID: hsa_circ_0075692
Name: hsa_circ_ATXN1
Synonym: -
Host Gene: ATXN1
Genomic location(hg19): chr6:16522857-16761721:-
Genomic location(hg38): chr6:16522626-16761490:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008487
MONDO name: polycystic ovary syndrome
Disease details: polycystic ovary syndrome
Disease DO ID:
 11612
Disease MeSH ID:
 D011085
Disease NCIt ID:
 C26862
Disease ICD11 ID:
 1213633323
Disease OMIM ID:
 184700
Species: Human
Species details: Homo sapiens
Tissue specimen:

follicular fluid
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-455-5p
Biological function: Potential diagnostic biomarker for PCOS.
Molecular mechanism: ceRNA mechanism (circRNA-miRNA-mRNA network) predicted by bioinformatics; not experimentally validated.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

An AUC value of 0.80 for hsa_circ_0075692 (95% CI: 0.78-1.00, **p <0.01) in distinguishing PCOS and normal controls.
Description:

hsa_circ_0075692 is up-regulated in PCOS follicular fluid and shows diagnostic potential (AUC 0.80). It is part of a bioinformatically predicted circRNA-miRNA-mRNA ceRNA network, without experimental validation of the downstream mechanism.
Confidence score:

0.5047
Other information
Title:

Identification of Three Potential circRNA Biomarkers of Polycystic Ovary Syndrome by Bioinformatics Analysis and Validation.

Journal: International journal of general medicine
Published: 2021
PubMed ID: 34588800
Study type:

combined biological and clinical study
Data availability: GSE145296; GSE155489; GSE138572
Code availability: -