| Expression pattern: |
DN |
| Associated gene: |
LATS2, Hippo/YAP signalling pathway, YAP, p-YAP |
| Associated microRNA: |
miR-141-3p |
| Biological function: |
inhibits proliferation, invasion and migration; promotes apoptosis; inhibits EMT; inhibits NSCLC progression in vitro and in vivo |
| Molecular mechanism: |
circ_100395 acts as a sponge for miR-141-3p to up-regulate LATS2 and suppress Hippo/YAP signaling (increased YAP phosphorylation, reduced YAP), leading to inhibition of NSCLC malignant phenotypes |
| Biological pathway or process: |
Hippo/YAP (inhibits); EMT (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
- |
| Description: |
circ_100395 is down-regulated in NSCLC tissues/cell lines. AMSC-derived exosomes delivering circ_100395 suppress NSCLC malignant phenotypes (proliferation, migration/invasion, EMT) and promote apoptosis by sponging miR-141-3p, thereby increasing LATS2 and inhibiting Hippo/YAP signaling. |
| Confidence score: |
0.7554 |