| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Potential diagnostic biomarker for NSCLC and may indicate late-stage disease progression. |
| Molecular mechanism: |
Not specified in platelets/NSCLC; the study focuses on expression-based biomarker validation rather than mechanistic dissection. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation |
| Clinical significance: |
circNRIP1 is significantly downregulated in platelets from NSCLC patients and its downregulation correlates with advanced (late-stage) disease, suggesting utility as a biomarker for NSCLC detection/progression. |
| Description: |
This study identifies platelet-derived circNRIP1 as significantly down-regulated in NSCLC patients versus asymptomatic controls by RNA-seq and confirms it by RT-qPCR in an independent cohort. The decrease is most evident in late-stage NSCLC, supporting circNRIP1 as a potential liquid-biopsy biomarker for NSCLC detection and progression monitoring. |
| Confidence score: |
0.3588 |