| Expression pattern: |
UP |
| Associated gene: |
FUS, ALYREF, ACIN1, EIF4A3, IGF2BP1, IGF2BP2, IGF2BP3 |
| Associated microRNA: |
- |
| Biological function: |
- |
| Molecular mechanism: |
Predicted circRNA-miRNA-mRNA and circRNA-RBP regulatory networks in gastric cancer. |
| Biological pathway or process: |
ceRNA regulation (other); apoptosis (other); p53 signaling (other); cell cycle (other); PI3K/AKT/mTOR (other); MAPK (other); HIF-1 signaling (other); TGF-beta/SMAD (other); Hippo/YAP (other); Wnt/beta-catenin (other); VEGF/VEGFR (other); EGFR (other); immune regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; RNA-seq |
| Clinical significance: |
Potential diagnostic biomarker in tissue and peripheral blood (ROC AUC > 0.70). |
| Description: |
hsa_circ_0000284 (circHIPK3) is up-regulated in gastric cancer in both gastric tissue and peripheral blood by RT-qPCR, suggesting diagnostic biomarker potential. The study additionally analyzes predicted circHIPK3-associated miRNA/mRNA and RBP interaction networks and enriches cancer-related pathways. |
| Confidence score: |
0.5267 |