circRNA basic information
circBase ID: hsa_circ_0000745
Name: hsa_circ_SPECC1
Synonym: -
Host Gene: SPECC1
Genomic location(hg19): chr17:20107645-20109225:+
Genomic location(hg38): chr17:20204332-20205912:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 1060198
MONDO name: ischemic stroke
Disease details: ischemic stroke
Disease DO ID:
 -
Disease MeSH ID:
 -
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral whole blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-140-5p
Biological function: Associated with ischemic stroke with increased expression; further research needed to confirm correlation.
Molecular mechanism: Predicted miRNA binding (miR-140-5p) from circRNA-miRNA network; otherwise not determined.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Relatively high diagnostic value (AUC 0.800).
Description:

hsa_circ_0000745 is up-regulated in peripheral whole blood from ischemic stroke patients and is proposed as a newly reported stroke-associated circRNA. It is included in a predicted circRNA-miRNA network (shared miR-140-5p) and shows diagnostic potential by ROC analysis (AUC 0.800), but requires further confirmation.
Confidence score:

0.5963
Other information
Title:

Screening for differentially expressed circRNAs in ischemic stroke by RNA sequencing.

Journal: BMC neurology
Published: 2021
PubMed ID: 34563140
Study type:

combined biological and clinical study
Data availability: GSE178764
Code availability: -