| Expression pattern: |
UP |
| Associated gene: |
HJURP, OIP5, RRM2 |
| Associated microRNA: |
miR-101-3p, miR-218-5p, miR-6720-3p |
| Biological function: |
unknown |
| Molecular mechanism: |
Predicted ceRNA sponge mechanism: hsa_circ_0077607 sponges miRNAs (hsa-miR-101-3p; hsa-miR-218-5p; hsa-miR-6720-3p) to indirectly regulate HJURP, OIP5 and RRM2 in LUAD. |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis |
| Clinical significance: |
Included as an upstream regulator in a circRNA-related ceRNA network used to construct a prognostic risk score model associated with OS/DFS and immune landscape in LUAD; circRNA-specific survival association not assessed due to lack of clinical information in GEO circRNA datasets. |
| Description: |
hsa_circ_0077607 was identified as an upregulated circRNA in LUAD and included in a prognostic ceRNA subnetwork. It is predicted to act as a miRNA sponge (miR-101-3p/miR-218-5p/miR-6720-3p) thereby indirectly affecting expression of HJURP, OIP5 and RRM2 that form a risk-score model linked to immune landscape and therapy sensitivity. |
| Confidence score: |
0.1768 |