circRNA basic information
circBase ID: hsa_circ_0001439
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr4:129913321-129925031:-
Genomic location(hg38): chr4:128992166-129003876:-
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma / LUAD
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum; serum-derived exosomes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Serum and serum exosomal hsa_circ_0001439 showed diagnostic value for LUAD and decreased after surgery; serum exosomal (but not serum) levels were associated with clinicopathologic status, and AUC in exosomes was reported.
Description:

hsa_circ_0001439 is elevated in LUAD patient serum and serum-derived exosomes and drops after tumor resection. It shows diagnostic potential (ROC AUC reported), with exosomal measurements performing better than serum measurements.
Confidence score:

0.459
Other information
Title:

Serum and Serum Exosomal CircRNAs hsa_circ_0001492, hsa_circ_0001439, and hsa_circ_0000896 as Diagnostic Biomarkers for Lung Adenocarcinoma.

Journal: Frontiers in oncology
Published: 2022
PubMed ID: 35747792
Study type:

clinical study
Data availability: The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.
Code availability: -