| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
hsa‐miR‐29b‐2‐5p, hsa‐miR‐29a‐5p, hsa‐miR‐518c‐5p, hsa‐miR‐214‐3p, hsa‐miR‐16‐5p |
| Biological function: |
may regulate TB-related miRNAs and be involved in active TB pathogenesis; diagnostic biomarker potential |
| Molecular mechanism: |
predicted miRNA sponge (circRNA-miRNA-mRNA interaction) with negative correlation to miR-29a and miR-16; functional prediction by GO/KEGG enrichment |
| Biological pathway or process: |
MAPK (other); Wnt/beta-catenin (other); autophagy (other); ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; ROC Analysis |
| Clinical significance: |
ROC curve analysis suggested diagnostic value for active TB (AUC 0.838) and could separate active TB patients from healthy controls |
| Description: |
hsa_circRNA_103571 is down-regulated in plasma of active TB patients and shows diagnostic potential (AUC 0.838). The study predicts a ceRNA-like mechanism where hsa_circRNA_103571 targets TB-related miRNAs (including miR-29a and miR-16) and links to downstream mRNAs; GO/KEGG enrichment suggests association with processes such as autophagy and pathways such as Ras and regulation of actin cytoskeleton. |
| Confidence score: |
0.5047 |