| Expression pattern: |
UP |
| Associated gene: |
E2F3 |
| Associated microRNA: |
miR-30c |
| Biological function: |
Promotes PTC cell proliferation, migration and invasion; induces anti-apoptotic effects. |
| Molecular mechanism: |
Acts as a competing endogenous RNA (ceRNA) sponging miR-30c to promote E2F3 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; CCK8; Colony Formation Assay; Transwell Assay; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
CircPRMT5 level was positively linked with advanced stage and lymph node metastasis in PTC tissues, suggesting potential clinical roles. |
| Description: |
CircPRMT5 is up-regulated in papillary thyroid cancer and promotes malignant phenotypes (proliferation, migration, invasion) while suppressing apoptosis. Mechanistically, it functions as a ceRNA that sponges miR-30c, thereby increasing E2F3 expression and driving PTC progression. |
| Confidence score: |
0.6996 |