| Expression pattern: |
DN |
| Associated gene: |
wnt3a, beta-catenin, phosphorylated YAP1 (p-YAP1), p53, p21, CyclinD1, Bax, Cleaved-Caspase-3 |
| Associated microRNA: |
miR-552 |
| Biological function: |
circSMARCA5 acts as an anti-tumor circRNA in colon cancer; its overexpression restrains cell viability, growth, colony formation, migration, invasion and xenograft tumor growth, while promoting apoptosis. |
| Molecular mechanism: |
circSMARCA5 directly sponges miR-552 and inhibits miR-552-mediated activation of Wnt and YAP1 pathways. |
| Biological pathway or process: |
Wnt/beta-catenin (inhibits); Hippo/YAP (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); cell cycle (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circSMARCA5 may be a potential therapeutic target for colon cancer. |
| Description: |
circSMARCA5 is down-regulated in colon cancer tissues and functions as a tumor suppressor. Its overexpression inhibits colon cancer cell growth, migration, invasion and xenograft tumor growth, promotes apoptosis, and acts mechanistically by sponging miR-552 to block Wnt and YAP1 pathway activation. |
| Confidence score: |
0.6544 |