circRNA basic information
circBase ID: hsa_circ_0004156
Name: hsa_circ_WHSC1
Synonym: circ‐WHSC1
Host Gene: WHSC1
Genomic location(hg19): chr4:1902352-1920350:+
Genomic location(hg38): chr4:1900625-1918623:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tumour tissues; adjacent normal tissues
Cell lines:

A549; NCI‐H460; HCC827; NCI‐H292; 95‐D; NCI‐H358; SW1537; BEAS‐2B
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: TAB2
Associated microRNA: miR-7
Biological function: promotes NSCLC cell proliferation, migration and invasion; promotes tumor growth in vivo
Molecular mechanism: Acts as a miRNA sponge for miR-7 to upregulate TAB2, enhancing downstream signaling (p38 MAPK, IKKbeta) and promoting NSCLC progression
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); MAPK (promotes); NF-kappaB (promotes); ceRNA regulation (promotes)
Detected method:
Q
S
Validation methods:

divergent primers PCR; RNase R Treatment; RT-qPCR; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis; Clinical Sample Validation; RNA-seq
Clinical significance:

-
Description:

circ-WHSC1 (hsa_circ_0004156) is up-regulated in NSCLC tissues and cell lines and promotes proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it functions as a ceRNA by sponging miR-7 to increase TAB2 expression, enhancing downstream p38 MAPK/IKKbeta signaling and accelerating NSCLC progression.
Confidence score:

0.8439
Other information
Title:

Circular RNA WHSC1 exerts oncogenic properties by regulating miR-7/TAB2 in lung cancer.

Journal: Journal of cellular and molecular medicine
Published: 2021
PubMed ID: 34551195
Study type:

combined biological and clinical study
Data availability: The data that support the findings are available from the corresponding author upon reasonable request.
Code availability: -