circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF609
Synonym: circRNA ZNF609
Host Gene: ZNF609
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

CC tissues; corresponding non-tumor tissues / adjacent non-tumor tissues
Cell lines:

End1/E6E7; HeLa; SiHa; HT-3; C-33A; Ca-Ski
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: E2F6
Associated microRNA: miR-197-3p
Biological function: Promotes cervical cancer cell proliferation, migration and invasion, and promotes tumor growth in vivo.
Molecular mechanism: Acts as a ceRNA (miRNA sponge) for miR-197-3p to upregulate E2F6.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; Bioinformatics Analysis; In Vivo Animal Model
Clinical significance:

-
Description:

circ-ZNF609 is up-regulated in cervical cancer tissues and cell lines and functions as an oncogenic circRNA. It sponges miR-197-3p to relieve repression of E2F6, thereby promoting proliferation, migration, invasion, and xenograft tumor growth.
Confidence score:

0.6479
Other information
Title:

Circular RNA ZNF609 functions as a competing endogenous RNA in regulating E2F transcription factor 6 through competitively binding to microRNA-197-3p to promote the progression of cervical cancer progression.

Journal: Bioengineered
Published: 2021
PubMed ID: 33734009
Study type:

combined biological and clinical study
Data availability: -
Code availability: -