| Expression pattern: |
UN |
| Associated gene: |
CXCL12 |
| Associated microRNA: |
miR-137 |
| Biological function: |
Enhances cisplatin resistance, promotes NSCLC cell viability, proliferation and xenograft tumor growth, and inhibits apoptosis under cisplatin treatment. |
| Molecular mechanism: |
circSNX6 promotes cisplatin resistance through a circSNX6/miR-137/ROS/CXCL12 axis, with miR-137 acting downstream of circSNX6 and CXCL12 acting as an effector downstream of miR-137. |
| Biological pathway or process: |
drug resistance (promotes); chemoresistance (promotes); proliferation (promotes); apoptosis (inhibits); ceRNA regulation (other); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Bioinformatics Analysis; Transfection; MTT; Colony Formation Assay; TUNEL; Western Blot; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
This study identifies circSNX6 as a promoter of cisplatin resistance in NSCLC cells. circSNX6 enhances cell viability, proliferation, and xenograft tumor growth while inhibiting apoptosis under cisplatin treatment, acting through a proposed circSNX6/miR-137/ROS/CXCL12 axis. |
| Confidence score: |
0.4635 |