| Expression pattern: |
UP |
| Associated gene: |
IGF1R, PI3K, AKT, mTOR |
| Associated microRNA: |
miR-30a-3p, hsa-miR-30d-3p, hsa-miR-2113, hsa-miR-30e-3p, hsa-miR-10b-3p |
| Biological function: |
promotes Osimertinib resistance, promotes proliferation, invasion and migration, and inhibits apoptosis in Osimertinib-resistant NSCLC cells |
| Molecular mechanism: |
ceRNA mechanism: circ_PPAPDC1A sponges miR-30a-3p to upregulate IGF1R and activate PI3K/AKT/mTOR signaling |
| Biological pathway or process: |
PI3K/AKT/mTOR (promotes); proliferation (promotes); invasion (promotes); migration (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); TUNEL; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
circ_PPAPDC1A may serve as a novel diagnostic biomarker and therapeutic target for NSCLC patients with Osimertinib resistance. |
| Description: |
circ_PPAPDC1A is up-regulated in Osimertinib-acquired resistant NSCLC tissues/cells and promotes resistance by enhancing proliferation, invasion and migration while inhibiting apoptosis. Mechanistically, it acts as a ceRNA sponging miR-30a-3p to upregulate IGF1R and activate the PI3K/AKT/mTOR pathway, and targeting circ_PPAPDC1A can partially reverse resistance. |
| Confidence score: |
0.7956 |