| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-19a-3p, miR-138-5p, miR-145-5p |
| Biological function: |
promotes Gemcitabine resistance; promotes survival under Gemcitabine treatment |
| Molecular mechanism: |
predicted miRNA sponge interaction with miRNAs (including miR-145-5p) in Gemcitabine resistance context |
| Biological pathway or process: |
chemoresistance (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; MTT; Annexin V/PI Flow Cytometry |
| Clinical significance: |
significantly up-regulated in plasma of Gemcitabine non-responsive PDAC patients vs responsive patients; potential biomarker and drug target for Gemcitabine non-responsive PDAC |
| Description: |
chr4:52729603-52780244+ is significantly up-regulated in gemcitabine-resistant PDAC models and in plasma of gemcitabine non-responsive PDAC patients. Knockdown restores gemcitabine sensitivity and increases apoptosis under gemcitabine; overexpression increases resistance in PANC-1 (but shows limited resistance phenotype in MIA PACA-2). It is predicted to interact with miRNAs such as miR-145-5p. |
| Confidence score: |
0.5923 |