circRNA basic information
circBase ID: -
Name: hsa_circ_BIRC6
Synonym: -
Host Gene: BIRC6
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004986
MONDO name: urinary bladder carcinoma
Disease details: bladder cancer
Disease DO ID:
 4007
Disease MeSH ID:
 -
Disease NCIt ID:
 C4912
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues
Cell lines:

SW780; T24; J82; 5637; SV-HUC-1
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: XBP1
Associated microRNA: miR-495-3p
Biological function: circ-BIRC6 knockdown suppresses proliferation, invasion, migration and EMT, and inhibits tumor growth in bladder cancer models.
Molecular mechanism: Acts as a ceRNA sponge for miR-495-3p to regulate XBP1 expression (circ-BIRC6/miR-495-3p/XBP1 axis).
Biological pathway or process:

proliferation (promotes); invasion (promotes); migration (promotes); EMT (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; IF (Immunofluorescence); In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis
Clinical significance:

-
Description:

In bladder cancer cell lines and xenografts, circ-BIRC6 is upregulated and promotes proliferation, invasion, migration and EMT. Mechanistically, circ-BIRC6 functions as a ceRNA by sponging miR-495-3p to increase XBP1 expression, thereby enhancing tumor growth and EMT-related protein changes.
Confidence score:

0.6544
Other information
Title:

Silencing circ‑BIRC6 inhibits the proliferation, invasion, migration and epithelial‑mesenchymal transition of bladder cancer cells by targeting the miR‑495‑3p/XBP1 signaling axis.

Journal: Molecular medicine reports
Published: 2021
PubMed ID: 34542161
Study type:

biological research
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -