circRNA basic information
circBase ID: hsa_circ_0005986
Name: hsa_circ_PRDM2
Synonym: -
Host Gene: PRDM2
Genomic location(hg19): chr1:14057494-14068652:+
Genomic location(hg38): chr1:13730999-13742157:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005086
MONDO name: renal cell carcinoma
Disease details: renal cell carcinoma / RCC
Disease DO ID:
 4450
Disease MeSH ID:
 D002292
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

RCC tissues; adjacent normal tissues; tumor samples; adjacent non-cancerous tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: CASP8, CCND1, CYCS
Associated microRNA: hsa-mir-21, hsa-mir-34a
Biological function: Potential tumor-suppressive role in RCC; proposed ceRNA-mediated regulation of CASP8, CCND1 and CYCS.
Molecular mechanism: Predicted ceRNA mechanism involving sponging of hsa-mir-21 and hsa-mir-34a to regulate CASP8, CCND1 and CYCS.
Biological pathway or process:

ceRNA regulation (other); apoptosis (other); cell cycle (other)
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

hsa_circ_0005986 had significantly lower expression in RCC patients with a history of kidney disease.
Description:

hsa_circ_0005986 was significantly downregulated in RCC tissues and in ccRCC samples. The paper predicts that it may function as a ceRNA by sponging hsa-mir-21 and hsa-mir-34a to regulate CASP8, CCND1 and CYCS, with a potentially important hsa_circ_0005986/hsa-mir-34a/CYCS axis in RCC progression.
Confidence score:

0.4685
Other information
Title:

Expression analysis of hsa_circ_0020397, hsa_circ_0005986, hsa_circ_0003028, and hsa_circ_0006990 in renal cell carcinoma.

Journal: Experimental and molecular pathology
Published: 2023
PubMed ID: 36496205
Study type:

combined biological, clinical and bioinformatics study
Data availability: GSE781; GSE6344; GSE14994; GSE16441; GSE17816; GSE17818; GSE17895; GSE26574; GSE36895; GSE40435; GSE40914; GSE46699; GSE53000; GSE53757; GSE68417; GSE71963; GSE55138; GSE41282; supplementary materials; data available on request
Code availability: -