| Expression pattern: |
UP |
| Associated gene: |
HOXA7 |
| Associated microRNA: |
miR-132 |
| Biological function: |
promotes proliferation, migration and invasion of oral cancer cells |
| Molecular mechanism: |
circVAPA acts as a miRNA sponge for miR-132, thereby regulating HOXA7 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot |
| Clinical significance: |
High circVAPA expression is associated with shorter overall survival and progression-free survival; correlated with tumor size, TNM stage and distant metastasis. |
| Description: |
circVAPA is up-regulated in OSCC tissues/cell lines and functions as an oncogenic circRNA. It promotes oral cancer cell proliferation, migration, and invasion by sponging miR-132 and relieving miR-132-mediated repression of HOXA7, and its high expression correlates with worse OS/PFS. |
| Confidence score: |
0.7537 |