circRNA basic information
circBase ID: hsa_circ_0029426
Name: hsa_circ_RAN
Synonym: -
Host Gene: RAN
Genomic location(hg19): chr12:131357380-131357465:+
Genomic location(hg38): chr12:130872835-130872920:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

LUAD tissues; normal lung tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Potential miRNA sponge (ceRNA) in LUAD
Molecular mechanism: ceRNA mechanism via miRNA response elements (MREs) within a circRNA-miRNA-mRNA network
Biological pathway or process:

ceRNA regulation (other); PI3K/AKT (other); HIF-1 signaling (other); other pathway/process (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

Could have diagnostic value for LUAD
Description:

hsa_circ_0029426 is down-regulated in LUAD and was incorporated into a predicted circRNA-miRNA-mRNA ceRNA network; downstream mRNAs associated with this network were enriched in pathways including PI3K-Akt and HIF-1 signaling, supporting potential diagnostic relevance.
Confidence score:

0.1768
Other information
Title:

Identification of Differentially Expressed Circular RNAs as miRNA Sponges in Lung Adenocarcinoma.

Journal: Journal of oncology
Published: 2021
PubMed ID: 34539783
Study type:

bioinformatics study
Data availability: GSE101586; GSE101684
Code availability: -