circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF292
Synonym: cZNF292
Host Gene: ZNF292
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0021042
MONDO name: glioma
Disease details: glioma
Disease DO ID:
 -
Disease MeSH ID:
 D005910
Disease NCIt ID:
 C3059
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

U87MG; U251
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: beta-catenin, PRR11, Cyclin A, CDK2, p-CDK2, VEGFR-1/2, p-VEGFR-1/2, EGFR, Axin, APC, STAT3, STAT5, p-STAT3, p-STAT5, E2F1, NF-kappaB, Sp1, HIF-1, AP-1, VEGF-A, EGF, TGF-beta1
Associated microRNA: -
Biological function: Promotes glioma cell proliferation, cell cycle progression, and tube formation (angiogenic potential); silencing inhibits these phenotypes.
Molecular mechanism: cZNF292 silencing represses Wnt/beta-catenin signaling and downstream cell-cycle regulators (e.g., Cyclin A/CDK2/PRR11), leading to S/G2/M arrest and reduced tube formation; also decreases activity of multiple transcription factors.
Biological pathway or process:

Wnt/beta-catenin (promotes); cell cycle (promotes); proliferation (promotes); angiogenesis (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; BrdU; Tube Formation Assay; Cell Cycle Assay; ELISA; Western Blot; Luciferase Reporter Assay
Clinical significance:

Potential therapeutic target and biomarker in glioma.
Description:

In human glioma cell lines, cZNF292 supports proliferation, cell-cycle progression and tube formation. Knockdown of cZNF292 induces S/G2/M arrest and suppresses Wnt/beta-catenin-related signaling and downstream effectors (e.g., Cyclin A/CDK2/PRR11) as well as tube formation-associated factors (VEGFR-1/2, EGFR).
Confidence score:

0.5301
Other information
Title:

Silencing of cZNF292 circular RNA suppresses human glioma tube formation via the Wnt/beta-catenin signaling pathway.

Journal: Oncotarget
Published: 2016
PubMed ID: 27613831
Study type:

biological research
Data availability: -
Code availability: -