| Expression pattern: |
DN |
| Associated gene: |
ARNT, TACC3, VEGF, VEGFA, VEGFR2, HIF1a |
| Associated microRNA: |
- |
| Biological function: |
Inhibits tumor angiogenesis by suppressing endothelial cell proliferation, migration, and differentiation; suppresses xenograft tumor growth in vivo. |
| Molecular mechanism: |
circ-0000437 encodes peptide CORO1C-47aa; CORO1C-47aa binds ARNT (PAS-B domain) and competitively blocks ARNT-TACC3 interaction, suppressing VEGF transcription and secretion, leading to reduced angiogenesis. |
| Biological pathway or process: |
angiogenesis (inhibits); proliferation (inhibits); migration (inhibits); other pathway/process (inhibits) |
| Detected method: |
Q
B
H
S
|
| Validation methods: |
RNA-seq; RT-qPCR; divergent primers PCR; RNase R Treatment; Sanger Sequencing; Northern Blot; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Transfection; RIP (RNA Immunoprecipitation); Western Blot; IF (Immunofluorescence); Co-IP; Luciferase Reporter Assay; ChIP / ChIP-seq; ELISA; CCK8; Wound Healing Assay; Transwell Assay; Tube Formation Assay; In Vivo Animal Model; H&E Staining |
| Clinical significance: |
- |
| Description: |
In endometrial cancer, circ-0000437 is down-regulated and encodes the peptide CORO1C-47aa. CORO1C-47aa binds ARNT (PAS-B domain), disrupts ARNT-TACC3 coactivation, suppresses VEGF/VEGFA signaling, and thereby inhibits tumor angiogenesis and reduces xenograft growth. |
| Confidence score: |
0.8536 |