| Expression pattern: |
UP |
| Associated gene: |
MMP2, Ago2 |
| Associated microRNA: |
miR-671-5p |
| Biological function: |
promotes proliferation, migration, invasion and angiogenesis; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ_0000620 sponges miR-671-5p to upregulate MMP2 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); metastasis (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Tube Formation Assay; Western Blot; In Vivo Animal Model; Survival Analysis; Clinical Sample Validation |
| Clinical significance: |
circ_0000620 could predict poor prognosis for GC patients |
| Description: |
circ_0000620 is upregulated in gastric cancer and mainly localized in the cytoplasm. It promotes malignant phenotypes (proliferation, migration/invasion, and angiogenesis) and tumor growth by acting as a sponge for miR-671-5p, thereby increasing MMP2 expression, and high circ_0000620 is associated with poorer survival. |
| Confidence score: |
0.8325 |