| Expression pattern: |
DN |
| Associated gene: |
TNRC6A, ERK1/2 |
| Associated microRNA: |
miR-185-5p |
| Biological function: |
inhibits proliferation and cell viability, induces apoptosis, and causes cell cycle arrest (blocks G0-to-S transition) in NSCLC cells |
| Molecular mechanism: |
acts as a ceRNA/miRNA sponge for miR-185-5p to relieve repression of TNRC6A and thereby regulate ERK1/2 phosphorylation |
| Biological pathway or process: |
ERK (inhibits); apoptosis (promotes); proliferation (inhibits); cell cycle (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circCDYL was decreased in NSCLC patients' tissues and plasma (potential biomarker mentioned) |
| Description: |
circCDYL is down-regulated in NSCLC tissues, plasma, and cell lines. Functionally, circCDYL suppresses proliferation/viability, induces apoptosis and cell-cycle arrest in A549 cells. Mechanistically, it sponges miR-185-5p to upregulate TNRC6A and inhibit ERK1/2 signaling. |
| Confidence score: |
0.7552 |