circRNA basic information
circBase ID: hsa_circ_0001821
Name: hsa_circ_PVT1
Synonym: hsa_circ_001821
Host Gene: PVT1
Genomic location(hg19): chr8:128902834-128903244:+
Genomic location(hg38): chr8:127890588-127890998:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma; CRC tissues; normal adjacent tissue
Cell lines:

HCT116; HT29; SW480; SW620; NCM460
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential biomarker for diagnosis of CRC, HCC and lung cancer; associated with advanced stage and poor prognosis in CRC.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Cohort Study
Clinical significance:

Plasma hsa_circ_0001821 is increased in CRC, HCC and lung cancer and shows diagnostic value by ROC; in CRC, high plasma hsa_circ_0001821 correlates with advanced stage and poorer prognosis and is an independent predictor by Cox regression.
Description:

The study reports that plasma hsa_circ_0001821 is up-regulated in CRC (also in HCC and lung cancer) and can serve as a noninvasive diagnostic biomarker with ROC performance. In CRC, higher plasma levels are associated with advanced stage and poorer overall survival, and hsa_circ_0001821 is an independent prognostic predictor in Cox regression.
Confidence score:

0.4992
Other information
Title:

Plasma circular RNA hsa_circ_0001821 acts as a novel diagnostic biomarker for malignant tumors.

Journal: Journal of clinical laboratory analysis
Published: 2021
PubMed ID: 34523755
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -