| Expression pattern: |
UP |
| Associated gene: |
SEMA4D, PI3K, AKT |
| Associated microRNA: |
miR-595 |
| Biological function: |
promotes cell growth/proliferation and suppresses apoptosis; promotes migration, invasion and EMT-like changes; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ_NRIP1 sponges miR-595 to de-repress SEMA4D, leading to activation of PI3K/AKT signaling |
| Biological pathway or process: |
PI3K/AKT (promotes); apoptosis (inhibits); proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Transfection; Colony Formation Assay; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
circ_NRIP1 expression was associated with TNM stage |
| Description: |
circ_NRIP1 (hsa_circ_0004771) is up-regulated in ESCC tissues and cell lines and acts as an oncogenic circRNA. It sponges miR-595 to increase SEMA4D, thereby promoting proliferation, migration/invasion and EMT-like changes while inhibiting apoptosis, and it supports tumor growth in a cell line-derived xenograft model via PI3K/AKT pathway activation. |
| Confidence score: |
0.7181 |