| Expression pattern: |
DN |
| Associated gene: |
PTEN, PI3K, p-AKT |
| Associated microRNA: |
miR-616-3p |
| Biological function: |
Downregulation/knockdown of circ_0000673 promotes proliferation and migration of endometrial stromal cells in endometriosis. |
| Molecular mechanism: |
circ_0000673 acts as a sponge for miR-616-3p, relieving repression of PTEN; loss of circ_0000673 increases miR-616-3p, reduces PTEN, and activates PI3K/p-AKT signaling. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); PI3K/AKT (promotes); ceRNA regulation (other) |
| Detected method: |
Q
H
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Western Blot; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ_0000673 is down-regulated in ectopic endometrium in endometriosis and mainly localizes to the cytoplasm. Its knockdown promotes endometrial stromal cell proliferation and migration by sponging miR-616-3p, thereby suppressing PTEN and activating PI3K/AKT signaling. |
| Confidence score: |
0.6815 |