circRNA basic information
circBase ID: -
Name: hsa_circ_PVT1
Synonym: -
Host Gene: PVT1
Genomic location(hg19): chr8:128902835-128903244:.
Genomic location(hg38): chr8:127890589-127890998:.
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0000872
MONDO name: B-cell childhood acute lymphoblastic leukemia
Disease details: pediatric B-precursor acute lymphoblastic leukemia
Disease DO ID:
 0080146
Disease MeSH ID:
 -
Disease NCIt ID:
 C9140
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood mononuclear cells (PBMCs)
Cell lines:

-
In vivo animal model:

patient-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: c-Myc, Bcl-2
Associated microRNA: miR-125, miR-let7, miR‐497
Biological function: unknown
Molecular mechanism: Likely miRNA sponging (miR-125, miR-let7, miR-497) based on prior studies cited; not experimentally tested here.
Biological pathway or process:

proliferation (other); apoptosis (other); ceRNA regulation (other); drug resistance (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; In Vivo Animal Model
Clinical significance:

-
Description:

circPVT1 is generally upregulated in pediatric BCP-ALL (qRT-PCR in PDX samples). The paper mainly contextualizes this finding with prior literature describing oncogenic, miRNA-sponge-based mechanisms (e.g., miR-125/let-7 and Bcl-2/c-Myc regulation), but does not experimentally test these mechanisms in this cohort.
Confidence score:

0.4128
Other information
Title:

Circular RNA differential expression in blood cell populations and exploration of circRNA deregulation in pediatric acute lymphoblastic leukemia.

Journal: Scientific reports
Published: 2019
PubMed ID: 31605010
Study type:

combined biological and clinical study
Data availability: GSE110159
Code availability: -