| Expression pattern: |
UP |
| Associated gene: |
ZEB1, MDM2 |
| Associated microRNA: |
miR-641 |
| Biological function: |
promotes OC cell growth, colony formation, migration, invasion and EMT |
| Molecular mechanism: |
ceRNA mechanism: ciRS-7 sponges miR-641 to up-regulate ZEB1 and MDM2, promoting EMT |
| Biological pathway or process: |
EMT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Transfection; CCK8; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; Bioinformatics Analysis |
| Clinical significance: |
High ciRS-7 expression was significantly associated with advanced TNM stages, lymph node metastasis status and decreased overall survival rate in OC patients |
| Description: |
In ovarian cancer, ciRS-7 is up-regulated and promotes tumor growth and metastatic phenotypes (migration/invasion) by enhancing EMT. Mechanistically, ciRS-7 functions as a ceRNA that sponges miR-641 to increase ZEB1 and MDM2 expression, and high ciRS-7 is associated with poorer overall survival. |
| Confidence score: |
0.7548 |