| Expression pattern: |
DN |
| Associated gene: |
E-cadherin, N-cadherin, vimentin, CyB1, CyD1 |
| Associated microRNA: |
miR-532-3p |
| Biological function: |
Suppresses breast cancer cell proliferation, migration and invasion; induces G2/M arrest; inhibits EMT. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-532-3p; miR-532-3p mimics reverse circRNA_103809-mediated anti-tumor effects; associated with EMT marker changes. |
| Biological pathway or process: |
proliferation (inhibits); cell cycle (other); migration (inhibits); invasion (inhibits); EMT (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Cell Cycle Assay; Transwell Assay; Western Blot |
| Clinical significance: |
Low circRNA_103809 expression is associated with distant metastasis, HER-2 status, TNM stage, and shorter overall survival; circRNA_103809 may be a prospective biomarker/therapeutic target. |
| Description: |
In breast cancer, circRNA_103809 is down-regulated and functions as a tumor suppressor. Its overexpression inhibits proliferation and migration/invasion, induces G2/M arrest, and suppresses EMT, at least partly by sponging miR-532-3p; higher circRNA_103809 expression is associated with better overall survival. |
| Confidence score: |
0.7113 |