circRNA basic information
circBase ID: -
Name: hsa_circ_TNS4
Synonym: circ7374
Host Gene: TNS4
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

normal colon mucosa; tumour tissue
Cell lines:

Caco-2; COLO 205; COLO 320HSR; DLD-1; HCT-15; HCT-8; HT-29; LS 174T; SW1116; SW480; SW620
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Lower circ7374/TNS4 ratio is associated with higher proliferation in CRC tissues.
Molecular mechanism: Despite being up-regulated as a circRNA, the circ7374/TNS4 ratio decreases with increasing proliferation (Ki-67), indicating global circRNA dilution relative to linear isoforms in proliferative CRC.
Biological pathway or process:

proliferation (inhibits)
Detected method:
Q
S
Validation methods:

RT-qPCR; RNase R Treatment; Clinical Sample Validation; IHC (Immunohistochemistry); RNA-seq
Clinical significance:

-
Description:

circ7374 (from TNS4) is reported as up-regulated in CRC by RNA-seq, yet its circRNA/linRNA ratio is reduced in tumors and significantly inversely correlated with Ki-67 proliferation, consistent with proliferation-driven global reduction of circular-to-linear transcript ratios.
Confidence score:

0.5662
Other information
Title:

Correlation of circular RNA abundance with proliferation--exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues.

Journal: Scientific reports
Published: 2015
PubMed ID: 25624062
Study type:

combined biological and clinical study
Data availability: SRA043728; SRP007584; SRP033095; E-MTAB-2399
Code availability: -