| Expression pattern: |
UP |
| Associated gene: |
RAB3D, AGO2 |
| Associated microRNA: |
miR-1253, miR-766-5p, miR-223-3p, miR-3139 |
| Biological function: |
Promotes NSCLC cell viability, migration and invasion; inhibits apoptosis; promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA (miRNA sponge) for miR-1253, thereby relieving repression of RAB3D and promoting NSCLC progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; IHC (Immunohistochemistry); TUNEL; In Vivo Animal Model; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High hsa_circ_0087862 expression was associated with poor prognosis and low 5-year survival in NSCLC patients. |
| Description: |
hsa_circ_0087862 is up-regulated in NSCLC and functions as an oncogenic circRNA. It promotes proliferation/viability, migration and invasion while inhibiting apoptosis, and it enhances xenograft tumor growth. Mechanistically, it sponges miR-1253 to increase the downstream target RAB3D, and higher circRNA expression is associated with poorer patient survival. |
| Confidence score: |
0.8282 |