circRNA basic information
circBase ID: -
Name: hsa_circ_FOXP1
Synonym: -
Host Gene: FOXP1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005086
MONDO name: renal cell carcinoma
Disease details: renal cell carcinoma
Disease DO ID:
 4450
Disease MeSH ID:
 D002292
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

renal cell carcinoma tissue; adjacent normal tissues
Cell lines:

HK-2; 293 T; ACHN; 786-O; OSRC-2; A 498; CAKI-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: U2AF2, AGO2, ZNF263
Associated microRNA: miR-423-5p
Biological function: Promotes RCC cell proliferation, migration, invasion, and the Warburg effect.
Molecular mechanism: Acts as a ceRNA that sponges miR-423-5p to upregulate U2AF2; circFOXP1 expression is induced by ZNF263.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); glycolysis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Transwell Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

circFOXP1 is a promising diagnosis and therapeutic target for RCC.
Description:

circFOXP1 is up-regulated in RCC tissues and cell lines and acts pro-tumorigenically by promoting proliferation, migration, invasion, and the Warburg effect. Mechanistically, it functions as a ceRNA to sponge miR-423-5p, thereby increasing U2AF2, and its expression is induced by ZNF263.
Confidence score:

0.8246
Other information
Title:

Circular RNA FOXP1 Induced by ZNF263 Upregulates U2AF2 Expression to Accelerate Renal Cell Carcinoma Tumorigenesis and Warburg Effect through Sponging miR-423-5p.

Journal: Journal of immunology research
Published: 2021
PubMed ID: 34514002
Study type:

combined biological and clinical study
Data availability: The data performed to support the findings of this study are included within the article.
Code availability: -